Dr. Michaela Höhne
Cofounder and CEO
Working Experience:
Since 11/2020
Postdoc at Center for Molecular Medicine Cologne
- Investigating the (epi)genome of tumours and their microenvironment by employing bioinformatics approaches
- Analysis of ChIP-Seq, RNA-Seq, CUT&Tag, DSBCapture, smartSeq3 and WES data
10/2015 – 08/2020
Research associate at University of Cologne
- Project planning and supervision of student assistants
-
Setting up and supervising a practical course for eight master students
- Analysis of high throughtput imaging data using redox ratio analysis and R and proteomics data using R
05/2010 – 06/2014
Student assistant at Fraunhofer Institute for Industrial Mathematics ITWM
- Data processing, test executions of programs, parameter estimations (R) intensive literature research, preparation of drafts and text modules for reports and papers
Educational history:
10/2015 – 08/2020
Doctoral candidate in molecular biochemistry, Prof. Jan Riemer, University of Cologne
“Metabolic control of mitochondrial H2O2 release at a glance”
10/2013 – 08/2015
Master of Science in Molecular Cell and Neurobiology, University of Kaiserslautern
10/2010 – 08/2013 Bachelor of Science in BioSciences, University of Kaiserslautern
Publications:
- Hoehne MN, Jacobs LJHC, Lapacz KJ, Calabrese G, Murschall LM, Marker T, Kaul H, Trifunovic A, Morgan B, Fricker M, Belousov VV, Riemer (2022), Spatial and temporal control of mitochondrial H2O2 release in intact human cells. EMBO J
- Bebber C, Thomas E, Stroh J, Chen Z, Androulidaki A, Schmitt A, Hoehne MN et al. (2021) Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nat Commun
- Szczepanowska K, Senft K, Heidler J, Herholz M, Kukat A, Hoehne MN et al. (2020) A salvage pathway maintains highly functional respiratory complex I. Nat Commun 11, 1643 (2020)
- Calabrese G, Peker E, Amponsah PS, Hoehne MN, et al. (2019) Hyperoxidation of mitochondrial peroxiredoxin limits H2O2-induced cell death in yeast. EMBO J 2019 Aug 7e:101552
- Habich M, Salscheider SL, Murschall LM, Hoehne MN, et al (2019) Vectorial Import via a Metastable Disulfide-Linked Complex Allows for a Quality Control Step and Import by the Mitochondrial Disulfide Relay. Cell reports 2019 Jan 15;26(3):759-774.e5.
Thorsten Höhne
Cofounder and CTO
Working Experience:
Since 11/2018
Produktionplaning in DLS
- Coordination of the production workflow
- Planing and prioritization of operations
- Determination of equipment and raw materials needed to meet production needs
- Calculation of competitive offers and implementation
07/2013 – 11/2018
Skilled Worker in DLS
- Major overhaul of disel engines
- Repair of turbochargers
- Process engine test bench including test dokumentation
Educational history:
08/2014 – 06/2018
State-certified meachanical engneering technician at Festo Lernzemtrum
(It’s an 4 year part time private school and the graduation is an equivalent to Bachelor of Engeneering)
08/2010 – 07/2013
Apprenticeship as an industiral mechanic in DLS
- Learning to produce workpieces and components
- Learning to evaluate technical drawings and create own assembly drawings
- Learining to assemble individual parts to complete machines, put them into operation and service them